Nigel J Pyne Selected Research

sphingosine kinase

1/2021	A new model for regulation of sphingosine kinase 1 translocation to the plasma membrane in breast cancer cells.
11/2020	A Novel Selective Sphingosine Kinase 2 Inhibitor, HWG-35D, Ameliorates the Severity of Imiquimod-Induced Psoriasis Model by Blocking Th17 Differentiation of Naïve CD4 T Lymphocytes.
11/2020	Recent advances in the role of sphingosine 1-phosphate in cancer.
1/2020	Sphingosine Kinase 1 Regulates the Survival of Breast Cancer Stem Cells and Non-stem Breast Cancer Cells by Suppression of STAT1.
1/2020	Sphingosine Kinases as Druggable Targets.
7/2017	Sphingosine kinase 2 and multiple myeloma.
1/2017	Effect of sphingosine kinase modulators on interleukin-1β release, sphingosine 1-phosphate receptor 1 expression and experimental autoimmune encephalomyelitis.
1/2017	Sphingosine Kinase 1: A Potential Therapeutic Target in Pulmonary Arterial Hypertension?
3/2016	Proteasomal degradation of sphingosine kinase 1 and inhibition of dihydroceramide desaturase by the sphingosine kinase inhibitors, SKi or ABC294640, induces growth arrest in androgen-independent LNCaP-AI prostate cancer cells.
1/2016	Sphingosine 1-phosphate and sphingosine kinases in health and disease: Recent advances.

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Nigel J Pyne Research Topics

Disease

22	Neoplasms (Cancer) 12/2020 - 07/2010
16	Breast Neoplasms (Breast Cancer) 01/2021 - 08/2010
7	Inflammation (Inflammations) 01/2020 - 07/2010
7	Prostatic Neoplasms (Prostate Cancer) 03/2016 - 10/2010
4	Multiple Sclerosis 01/2017 - 10/2010
4	Pulmonary Hypertension 01/2017 - 12/2002
3	Disease Progression 01/2017 - 01/2016
3	Pulmonary Arterial Hypertension 01/2017 - 01/2013
3	Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental) 01/2017 - 01/2016
3	Hypoxia (Hypoxemia) 05/2006 - 12/2002
2	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 12/2021 - 09/2014
2	Carcinogenesis 01/2021 - 07/2010
2	Hypertension (High Blood Pressure) 01/2020 - 03/2013
2	Pheochromocytoma 09/2006 - 01/2004
1	Relapsing-Remitting Multiple Sclerosis 12/2020
1	Psoriasis (Pustulosis Palmaris et Plantaris) 11/2020
1	Lung Neoplasms (Lung Cancer) 01/2020
1	Multiple Myeloma 07/2017
1	Vascular Remodeling 01/2017
1	Pancreatic Neoplasms (Pancreatic Cancer) 01/2016
1	Right Ventricular Hypertrophy 01/2016
1	Hypertrophy 01/2016
1	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma (T-ALL) 09/2014
1	Colonic Neoplasms (Colon Cancer) 01/2013
1	Macular Degeneration (Age-Related Maculopathy) 01/2013
1	Fibrosis (Cirrhosis) 01/2013
1	Vascular System Injuries 02/2010
1	Hyperplasia 02/2010
1	Infections 04/2008

Drug/Important Bio-Agent (IBA)

33	sphingosine kinaseIBA 01/2021 - 05/2006
24	sphingosine 1-phosphate (sphingosine-1-phosphate)IBA 11/2020 - 02/2010
10	LipidsIBA 01/2016 - 05/2006
8	SphingosineIBA 11/2020 - 08/2011
8	EnzymesIBA 11/2020 - 10/2010
7	Fingolimod Hydrochloride (FTY720)FDA Link 12/2020 - 10/2010
7	Sphingosine-1-Phosphate ReceptorsIBA 06/2018 - 05/2006
6	Phosphotransferases (Kinase)IBA 11/2020 - 11/2011
6	AndrogensIBA 03/2016 - 10/2010
5	Protein Isoforms (Isoforms)IBA 11/2020 - 09/2012
5	Proteins (Proteins, Gene)FDA Link 01/2016 - 12/2002
4	DNA (Deoxyribonucleic Acid)IBA 06/2018 - 10/2011
4	SphingolipidsIBA 03/2016 - 06/2013
4	Ether (Diethyl Ether)IBA 01/2016 - 10/2011
4	Estrogen ReceptorsIBA 05/2014 - 08/2010
3	Pharmaceutical PreparationsIBA 11/2020 - 11/2011
3	Small Interfering RNA (siRNA)IBA 03/2016 - 04/2008
3	Mitogen-Activated Protein KinasesIBA 01/2016 - 04/2003
3	Messenger RNA (mRNA)IBA 05/2006 - 12/2002
2	3- (4- chlorophenyl)- adamantane- 1- carboxylic acid (pyridin-4-ylmethyl)amideIBA 11/2020 - 03/2016
2	LyasesIBA 11/2020 - 01/2013
2	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 06/2018 - 01/2012
2	dihydroceramide desaturaseIBA 03/2016 - 01/2016
2	InflammasomesIBA 01/2016 - 01/2016
2	PF-543IBA 01/2016 - 01/2016
2	ResveratrolIBA 12/2014 - 07/2012
2	((E)- 3- amino- 5- (4- heptylphenyl)- 3- (hydroxymethyl)pent- 1- enyl)phosphonic acidIBA 06/2013 - 10/2010
2	Biomarkers (Surrogate Marker)IBA 02/2013 - 01/2012
2	Lysophosphatidic Acid ReceptorsIBA 01/2013 - 05/2006
2	lysophosphatidic acidIBA 01/2013 - 09/2006
2	CeramidesIBA 09/2012 - 12/2010
2	Mitogen-Activated Protein Kinase 3IBA 11/2010 - 11/2010
2	Peptides (Polypeptides)IBA 04/2008 - 12/2002
2	Nerve Growth Factor (NGF)IBA 09/2006 - 01/2004
2	Phosphoric Diester Hydrolases (Phosphodiesterases)IBA 04/2003 - 12/2002
1	Interleukin-7 (Interleukin 7)IBA 12/2021
1	safingol (sphinganine)IBA 12/2020
1	Therapeutic UsesIBA 11/2020
1	Imiquimod (Aldara)FDA LinkGeneric 11/2020
1	Insulin (Novolin)FDA Link 01/2019
1	Extracellular Signal-Regulated MAP Kinases (Extracellular Signal Regulated Kinases)IBA 06/2018
1	FenretinideIBA 03/2016
1	ThiazolesIBA 03/2016
1	Platelet Activating FactorIBA 01/2016
1	1-(4-octylphenethyl)piperidin-4-olIBA 01/2016
1	Glycerol (Glycerine)FDA LinkGeneric 01/2016
1	platelet activating factor receptorIBA 01/2016
1	Tyrosine (L-Tyrosine)FDA Link 05/2014
1	lysophosphatidylinositolIBA 06/2013
1	4- (4- (4- chloro- phenyl)thiazol- 2- ylamino)phenolIBA 04/2013
1	diadenosine triphosphate (ApppA)IBA 04/2013
1	fragile histidine triad proteinIBA 04/2013
1	Androgen Receptors (Androgen Receptor)IBA 03/2013
1	Amino Acids FDA Link 09/2012
1	ampelopsinIBA 07/2012
1	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 02/2012
1	Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA 02/2012
1	Enzyme Inhibitors (Inhibitors, Enzyme)IBA 05/2011
1	Tamoxifen FDA LinkGeneric 11/2010
1	human ERBB2 proteinIBA 08/2010
1	Oxygen (Dioxygen)IBA 07/2010
1	N,N-dimethylsphingosineIBA 02/2010
1	3- (4- (4- ((1- (2- chlorophenyl)ethoxy)carbonyl amino)-3-methyl-5-isoxazolyl) benzylsulfanyl) propanoic acidIBA 09/2006
1	Phosphates (Orthophosphate)IBA 05/2006
1	p38 Mitogen-Activated Protein KinasesIBA 05/2006
1	Phorbol EstersIBA 05/2006
1	Cyclic GMPIBA 04/2003

Therapy/Procedure

2	Drug Therapy (Chemotherapy) 11/2020 - 01/2020
2	Therapeutics 09/2014 - 07/2010
1	Precision Medicine 11/2020
1	Radiotherapy 01/2020